Design, Development and Evaluation of Eucalyptol Transdermal Patch for Anti-Diabetic Activity
نویسندگان
چکیده
For almost two hundred years, diabetes mellitus has been a major health problem worldwide. While there progress in our knowledge of its pathophysiology and treatment, the therapeutic choices available today are woefully inadequate. The goal transdermal medication delivery systems is to provide therapeutically effective doses medicine via skin. released at steady, regulated pace thanks design these devices. As result, it well suited for management long-term conditions like diabetes. Thus, risks inconvenient nature oral parenteral routes avoided. purpose this study develop test eucalyptol patches treatment Drug distribution from different polymer-based might be enhanced by using oleic acid as penetration enhancer. Matrix-style patches, composed PVP K30, HPMC K100, solvent, were created utilizing solvent casting procedures. By Fourier transform infrared spectroscopy, researchers able examine drug's polymers' physicochemical compatibility. No evidence physical or chemical incompatibility between polymers was found. also underwent battery tests addition in-vivo research. with polymers, that is, enhancer, regarded best formulations based on findings obtained assessment, ex vivo investigations, studies.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2022
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2022.13.s08.449